Targeted Deletion of MMP 9 Attenuates
Selected Abstract
Targeted Deletion of MMP-9 Attenuates Myocardial Contractile Dysfunction in Heart Failure
Summary Chronic volume overload (VO) on the left ventricle (LV) augments redox stress and activates matrix metalloproteinase (MMP) which causes the endocardial endothelial-myocyte (EM) disconnection leading to myocardial contractile dysfunction. VO-induced MMP-9 activation impairs cardiac ... May 1, 2008; Physiological Research
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Targeted Deletion of MMP-9 Attenuates Myocardial Contractile Dysfunction in Heart Failure
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